Retinoblastoma is an uncommon kind of retinal malignancy that typically affects young children. Retinoblastoma was the first gene found to be capable of suppressing tumor growth. This discovery opened up new avenues for research in the field of oncology and led to the identification of 35 tumor suppressor genes in the human genome. This publication is a comprehensive compilation of both basic and advanced information that can simultaneously serve novice and seasoned physicians. This book also includes a substantial quantity of material on the most recent developments and cutting-edge understanding of the intracellular molecular cross-talking of retinoblastoma protein with different cellular viral-like proteins.