This book uses a wealth of data to mainly address the subject of tumor suppressor genes. Considerable data from somatic cell fusion studies suggests that a subset of genes from healthy cells may be able to restore or replace a malfunctioning function in cancer cells. The study of hereditary retinoblastoma led to the development of tumorigenesis that might be induced by two mutations, ultimately resulting in the cloning of the RB1 gene. Since then, the two-hit theory has aided in the identification of several tumor suppressor genes (TSG). Recently, descriptive analyses have been conducted on the functions of haploinsufficiency, gene dosage consequences, and epigenetic control in a few TSGs, including PTEN, P16, and P53.


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  • SKU: 9781632424129
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Product details

  • Publisher ‏ : ‎ Foster Academics (23 January 2015)
  • Language ‏ : ‎ English
  • Hardcover ‏ : ‎ 346 pages
  • ISBN-10 ‏ : ‎ 1632424126
  • ISBN-13 ‏ : ‎ 978-1632424129
  • Item Weight ‏ : ‎ 630 g
  • Dimensions ‏ : ‎ 15.24 x 2.06 x 22.86 cm
Editor
Eden Dennis
Publisher
Foster Academics